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Consistent with this idea, the authors found that AGO4's RNA slicing activity is needed to achieve high levels of DNA methylation at target sites throughout the genome.
Source: https://phys.org/news/2023-02-argonaute-protein-slicing-retention-rna.html
They were also asked to eat two servings daily of methylation adaptogens—foods that support DNA methylation, a process that controls gene expression.